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Anatomical proximity to radiosensitive organs such as the bladder, rectum, and bowel restricts dose escalation and exposes patients to long-term toxicities including fibrosis, necrosis, sexual dysfunction, and urinary or bowel complications [14,15,16]

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Whats nice with this class of medicines is that kidney protection is an added bonus: There is already evidence that they benefit in terms of weight loss and cardiovascular health, so physicians would have more than one reason to consider them, Anand said

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