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These factors enter the systemic circulation, leading to a host systemic inflammatory response characterized by increased synthesis of acute-phase proteins (e.g., CRP), accelerated generation and mobilization of neutrophils from the bone marrow, and increased apoptosis of lymphocytes (43)
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This emphasizes the challenge of interpreting pooled results across diverse study populations and highlights the need for patient-level data to understand treatment response in HFpEF better
For vascular dementia, no significant difference was observed