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[6] Phase III ACHIEVE-1 trial [edit] In April 2025, results from a phase III clinical trial involving 559 people with type 2 diabetes who took an oral orforglipron pill or a placebo daily for 40 weeks showed that orforglipron produced a reduction of hemoglobin A1C level by 1.3 to 1.6 percentage points from a starting level of 8%

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This report also contains projected trends for these formulations, and some information on the uses of these supplements for specific ailments (e.g., osteoarthritis)

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