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Fruergaard Jrgensen acknowledged the criticism, particularly around the firm's failure to accurately communicate the flexible trial design, which raised questions over tolerability, with fewer than two-thirds of patients progressing to the highest dose after 68 weeks

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The following benefits are derived from animal model research and require validation in human populations

Chronic cocaine exposure has been linked to an increased risk of Parkinsons disease, as it promotes -synuclein overexpression in dopamine neurons, causing resting tremors and neurotoxic damage (Mash et al., 2003)