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(2014) demonstrated that although L-carnitine administration reduced muscle cramping in certain studies (2 trials, 102 participants), it did not significantly lower the occurrence of intradialytic hypotension (3 trials, 128 participants)

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It is a reasonable supplement to a balanced diet but not a reliable substitute for a full electrolyte mix during sustained exercise or heat exposure

A proof of the dynamic balancing of carnitine homeostasis derives from the observation that, under regular diet, patients carrying defects of the carnitine biosynthesis enzymes, do not apparently display carnitine deficiency, because the reduced synthesis is compensated by carnitine dietary intake and increased renal reabsorption (Stanley et al., 1992