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Metabolic dyslipidemia and cardiovascular outcomes in type 2 diabetes mellitus: findings from the look AHEAD study

Semaglutide targets one gut hormone receptor, GLP-1

The most closely watched data for retatrutide to date come from its Phase 2 clinical trial , published in The New England Journal of Medicine in 2023 (Jastreboff et al.), which demonstrated substantial weight reduction across dose groups

Retatrutide at 12 mg produced 24.2% in 48 weeks in Phase 2, with the curve still descending

Each dose increase can bring a temporary return of side effects, sometimes stronger than what you experienced at the previous level