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Recently, GLP-1 was shown to act on GLP-1R and exert its neuroprotective effects by promoting PTEN-induced kinase 1/Parkin-mediated mitochondrial autophagy and attenuating OS (Wang Y

L-carnitine and other trimethylamine (TMA) containing compounds (including GBB and crotonobetaine) can be further metabolized by gut bacteria to yield free TMA (Koeth et al., 2014

This led to the US Food and Drug Administration (FDA)-approved indication for subcutaneous semaglutide for reducing MACE in patients with T2D and CVD [23, 30]

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Studies show that many people see a clear drop in their body mass and body weight