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A 2023 meta-analysis of 26 randomized controlled trials (1,721 participants) found hydrolyzed collagen significantly improved skin hydration and elasticity versus placebo, with benefits typically appearing after 812 weeks of daily use

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The other is it can break down in stomach acid, requiring the body to put it back together (which is nutrient intensive)

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Understanding your genetic predisposition to lower antioxidant capacity alongside biomarker data can support a more informed conversation with your provider about whether glutathione supplementation is clinically justified and which form may offer the best value for your specific situation