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Locally, topical application of active analogues such as calcipotriol offers spatial precision to selectively activate VDR-dependent pathways, thereby suppressing superficial inflammation, repairing oxidative damage, and regenerating the epidermal barrier

Libraries from parallel labeling were combined after checking the activity of each population

Pfeiffer CM, Caudill SP, Gunter EW, Osterloh J, Sampson EJ

Lysates were incubated with the anti-Nrf2 antibody (Proteintech, 66504-1-lg), anti--arrestin2 antibody (Santa Cruz, sc-514791), or mouse IgG conjugated to sepharose beads (Cell Signaling Technology, 3420)

This is also where most of the controversy lies: Injections: This is the fastest-acting and most potent route, but it carries serious risks including allergic reactions, infections, kidney or thyroid damage, toxicity and ochronosis