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In addition, individuals who may be vitamin K deficient due to liver failure, those with a propensity to bleed (e.g., bleeding peptic ulcers), and those with inherited bleeding disorders (e.g., hemophilia) or a history of hemorrhagic stroke, should not take -tocopherol supplements without close medical supervision because of the increased risk of hemorrhage (119, 128)

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The tissue lacks the robust blood supply that muscles enjoy, receives constant mechanical loading that disrupts healing, and often develops fibrotic scar tissue rather than healthy organized collagen

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Oxidative stress induces autophagy in response to multiple noxious stimuli in retinal ganglion cells