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A shortage of a commercially available drug is one of the criteria that allows compounded production, as per FDA legislation

doi: 10.1007/s11102-017-0849-z 22 BlumWFAlbertsson-WiklandKRosbergSRankeMB

Sun X, Chen WD, Wang YD (2017) DAF-16/FOXO transcription factor in aging and longevity

Insulin governs developmental processes and exerts influence on ovarian physiology as well as pathology [49, 55]

References The USADA or anti-doping agency statement FDA bulletin, Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks PubMed list of papers Also see my newer peptides post that provides more context on peptides and compounding as well as FDA oversight along with political impacts