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These inflammatory changes highlight how obesity exacerbates asthma severity and impacts treatment responses [10], suggesting that both conditions may represent manifestations of general systemic inflammation of the immune system [61]

doi: 10.1016/j.redox.2015.08.020 96 NakahiraKKyungSYRogersAJGazourianLYounSMassaroAFet al

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Experimental literature around thymosin 4 motifs includes anti-apoptotic signaling through Akt/PKB, modulation of PTEN-PI3K circuitry, and shifts in cytokine profilesreducing TNF-/IL-6 while supporting IL-10consistent with a transition from a pro-inflammatory state to a more reparative milieu