Interestingly, two thirds of such replacements are in highly and moderately conserved (50% to 99%) amino acids, and relatively few are in fully conserved amino acids (where they might be lethal) or in poorly conserved amino acids, where presumably they simply would not cause G6PD deficiency
Mitochondrial cytochrome c oxidase deficiency
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Its antibacterial mechanism of action involves the inhibition of bacterial DNA-replication enzymes, DNA gyrase A and topoisomerase IV
8 CT-996, an investigational, once-daily, oral small molecule GLP-1 receptor agonist being developed for the treatment of both type 2 diabetes and obesity, currently in Phase I, with the potential to be a best-in-class oral treatment for type 2 diabetes and chronic weight management