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In practice, combining the cost of the skin punch biopsy, immunostaining, and specialist histopathological review might plausibly reach 200300 per sample, based on internal cost accounting in neuropathy research centers (though published examples are rare)

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JAMA Intern Med, 2015

Materials and methods Animals Male Sprague Dawley rats, aged 13 months, were used in behavioral, physiological, and histological studies of noise-induced pathology and tinnitus

This mechanism is particularly beneficial for individuals with type 2 diabetes or prediabetes, as better glucose regulation can reduce the risk of long-term complications associated with high blood sugar levels