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These findings suggest that targeting the regulation of gut microbiota and metabolites such as itaconate to control oxidative stress represents a promising novel therapeutic strategy for SLE

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Liu Z, Ren Z, Zhang J, Chuang C, Kandaswamy E, Zhou T, et al

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It was originally derived from a protein fragment associated with gastric juice and studied for its protective effects on the gastrointestinal system. Since its development in the 1990s, research has expanded into musculoskeletal healing, where it has shown promising effects in animal models involving tendon, ligament, muscle, and bone injuries. One important caveat regarding BPC-157 is that it is not FDA-approved for human use, and most of what we know comes from preclinical research