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Although multiple pathways are involved in mediating tissue damage, including the polyol pathway, advanced glycation end product formation, protein kinase C activation, and the hexosamine pathway, a common feature is increased oxidative stress marked by elevated levels of reactive oxygen species (ROS) (1)

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4 Insulin-like growth factor binding protein-likes (IGFBPLs) The term IGFBPLs refers to a group of proteins that share structural similarities with the IGFBPs

doi: 10.1016/j.freeradbiomed.2019.05.035 286 ValdsA.Ortega MorenoL.Rojo RelloS.OrduaA.BernardoD.CifuentesA

SeNPs offer several advantages over conventional Se compounds, such as sodium selenite or SeMet [107]