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Research has shown that BAs in combination with its activating transcription factor, farnesoid X receptor (FXR), inhibit cholesterol transport and increase cholesterol excretion by macrophages in order to reduce cholesterol concentration in plasma, and can be used as a therapeutic target for dyslipidemia (Figure 2

The terms of this arrangement are being managed by the Johns Hopkins University (JHU) in accordance with its conflict-of-interest policies

Every breakthrough begins with a question, followed by years of research, testing, collaboration, and refinement

Common symptoms include chronic fatigue, poor sleep quality, brain fog, frequent illness, and muscle or joint pain

Statistical differences between two groups for behavioral tests were determined with Students t test, and statistical differences among three groups or more were determined using a one-way analysis of variance (ANOVA), two-way ANOVA, and an ANOVA with repeated measures, followed by Bonferronis multiple comparison test