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Normal total testosterone ranges from approximately 300-1,000 ng/dL, though many men begin experiencing symptoms when levels drop below 500 ng/dL

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In addition, patients should be encouraged to engage in lifestyle modifications and the prescribing clinician should periodically assess patient engagement in these behaviours and provide support to patients to engage in further changes

Additionally, our collaborating clinicians and pathologists at Shanghai Ninth Peoples Hospital have observed the development of hyperpigmentations adjacent to OMM in a majority of patients and they suspect that tumors expand through those de novo pigmented lesions ( Figures 1D )