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A 2025 systematic review in the International Journal of Dermatology documented liver function abnormalities in approximately half of IV-treated participants at high doses, which is why DermaVue restricts treatment to evidence-based clinical doses of 400 to 1200 mg with mandatory hepatic monitoring

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[PubMed] [Elsevier] 84

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Two recent studies found that S- and RBD-specific immunoglobulin G (IgG) antibodies in patients with COVID-19 have lower levels of fucosylation within their Fc domains 26,27 a phenotype linked to higher affinity for FcRIIIa, an activating Fc receptor (FcR) that mediates antibody-dependent cellular cytotoxicity