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This was accompanied by notable improvements in fasting glucose and insulin sensitivity indices derived from standardized mixed-meal tolerance testing (sMMTT)

* The Difference Median column refers to the median of the observed differences between the values of the subjects biomarkers at a given date and the baseline (e.g., the median of the observed differences between the platelet count on days D14 and D01)

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This is not trivial, but it was dwarfed by spending on immunosuppressants and other specialties (for perspective, Humira alone likely approached or exceeded that figure in the state)