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Our data reveals a novel synergistic neuroprotection wherein N-3 PUFAs enhance VDR expression, thereby amplifying Vit Ds capacity to regulate gene networks involved in neuroprotection, and potentiating the anti-inflammatory and anti-apoptotic pathways, while tackling pathological protein aggregations, a common hallmark in multiple neurodegenerative diseases

Periodic monitoring of serum B 12 levels should be obtained to establish adequacy of therapy

To increase aqueous solubility of the compounds to facilitate structural studies, the cycloheptyl substituent in TGR uncompetitive inhibitor 8 was replaced with a sugar moiety, resulting in compound 9 , a noncompetitive inhibitor and thus capable of binding the enzyme in absence of NADPH

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Quantitative efficacy of L-carnitine supplementation on glycemic control in type 2 diabetes mellitus patients