Many studies have found that carotenoids can affect the expression of cell cycle-related proteins, such as increasing the levels of the cell cycle inhibitors p21Cip1 and p27Kip1, while inhibiting the activity of Cyclin and its related kinases, thereby inducing cell cycle arrest in cancer cells ( In addition to inhibiting proliferation, carotenoids affect the cellular DNA damage response pathway, enhancing p53-mediated gene monitoring and repair
At Cymbiotika, we believe that understanding the "when" is just as important as the "how," especially when it comes to maximizing cellular absorption
Contemporary oncology supports network-based treatment methods, as the simultaneous suppression of the PI3K/AKT/mTOR, MAPK/ERK, and NF-B pathways disrupts survival mechanisms while preventing adaptive resistance and extending apoptosis duration 59
NF-kappaB: emerging roles in hippocampal development and function
Harvey BH, Joubert C, du Preez JL, Berk M