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The distribution of IGF-I in serum and skeletal environment is an important component of IGF-I action, and is determined by the relative saturation by IGFBPs

It is not a replacement for established lipid-lowering therapies but may offer complementary metabolic benefits

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Individuals with insulin resistance, visceral adiposity, hypertension, and endothelial dysfunction exhibit early declines in cerebral blood flow and metabolic flexibility, long before overt dementia emerges

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