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MicroRNAs are a category of non-coding RNAs featuring a 22-base sequence, which exert regulatory effects on gene expression via post-transcriptional modification of target mRNAs (Makeyev and Maniatis, 2008), studies have indicated that microRNAs participate in numerous key biological processes, including cell proliferation and apoptosis (Huber et al., 2015

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N Engl J Med 2016;375(19):183444

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