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Patients with diabetes need particularly careful monitoring during combination therapy

NICE guidance on obesity (CG189: Obesity: identification, assessment and management) and lifestyle weight management services (PH53) emphasises structured lifestyle interventions, behavioural support, and where clinically appropriate pharmacological treatment prescribed by a clinician, rather than over-the-counter supplements

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E.BoruchA

Human studies are important but still depend on specific trial designs and development-stage evidence