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There are no absolute food restrictions, but most patients find that high-fat, greasy foods worsen nausea and gastrointestinal side effects

In SURMOUNT-1, tirzepatide at 15 mg weekly produced 22.5% average weight loss over 72 weeks

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Recent trials have shown: Up to 20% body weight reduction with weekly GLP-1 agonists (Wilding et al., NEJM) Improvements in HbA1c, fasting glucose, and cardiovascular outcomes (Marso et al., NEJM) This drug class is now widely used for: Obesity (with or without diabetes) Type 2 diabetes PCOS-related insulin resistance Metabolic syndrome Common Side Effects and Patient Concerns Despite their benefits, GLP-1 agonists are not without risks or drawbacks

weighed 198 lbs, a 40-lb weight loss with four inches off his waistline