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Slow gastric emptying, keeping food in the stomach for longer which contributes to sustained feelings of fullness (1,2,3)

In other words, we performed experiments in which we first applied cilostamide and retatrutide and then we added as an antagonist either exendin9-39, ProGIP, or SC203979

Potential Beneficial Effects of Butyrate in Intestinal and Extraintestinal Diseases

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The fact that these drugs based off our hormones are stable seems to be important to the longer-term effects were witnessing in pancreatic beta cells and other tissues, explained first author Sam Van de Velde, a staff scientist in Montminys lab