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Conclusions The publication of the 2024 NICE guidelines on B 12 deficiency represents progress but falls short by proposing to rename pernicious anaemia with autoimmune gastritis. This change does not adequately address the distinct nature of PA as an advanced stage of AIG, characterised by IF deficiency requiring lifelong B 12 treatment

1 Sm TG extracted from the BY4741-TG strain was used

Correct insertion of dsbA deletion in marker free gshA was checked using appropriate primers (Supplementary table S3)

Abstract Background Sickle cell disease is a fatal systemic condition characterized by acute painful episodes, persistent anemia, ongoing organ damage, organ infarction, and a markedly shorter average lifetime

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