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A compelling area for future research is to investigate whether GLP-1-RAs modulate taste perception in part by altering the expression or signaling of leptin or cholecystokinin (CCK) in taste bud cells, creating an integrated hormonal milieu that fine-tunes taste sensitivity based on energy status

It forms a complex with TFE3 and TRIM28 that enhances H3K4me3, an activating mark, at the promoters of ATG5, LC3B , and GABARAPL1 , thus leading to their transcriptional upregulation

doi: 10.1016/j.ab.2010.07.002 164 Gonzalez-RianoCGarciaABarbasC

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