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The outcomes for this secondary mechanistic analysis from SUMMIT were identified on the basis of pathophysiologic understanding of obesity-related HFpEF as variables that we hypothesized would change with tirzepatide treatment, including measures of BP, estimated BV and PV, kidney function, albuminuria, cardiac injury, inflammation and cardiac distention (reflected by NT-proBNP)

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Mathematical modelling suggests dosing every other week might retain 75% of effectiveness, but patient reports indicate noticeable increases in hunger and appetite during off weeks

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