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In addition to tau aggregates from hyperphosphorylation, Alzheimers disease can develop from high amounts of oxidative stress in the brain, which involves excessive amounts of inflammatory and damaging compounds called reactive oxygen species (ROS)

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Subsequently, each system underwent independent simulations lasting 500 ns each (totaling 1.5 s per system) at 298 K, employing the Langevin thermostat with a time step of 0.2 fs

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