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But based on the published data, I do not think one can reasonably claim that retatrutide is muscle sparing

I would say the postmenopausal women I treat are not typically super responders, she says

Early clinical trials have demonstrated: Up to 24% weight loss in patients over 48 weeks Significant reduction in visceral fat as measured by MRI Improvements in insulin sensitivity and lipid profiles Unlike earlier GLP-1s, retatrutide offers broader metabolic effects by engaging multiple hormonal pathways

10.1210/jcem.80.3.7883856 J

4 Meanwhile, the European Medicines Agencys Pharmacovigilance Risk Assessment Committee concluded that available evidence does not support a causal link between GLP-1 receptor agonists and suicidal or self-injurious thoughts and actions