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This in turn stimulates the selenoproteins to convert more T4, and the hydrogen peroxide continues to build up instead of being neutralized

Moreover, epigenetic studies have revealed that BDE-47 induced demethylation of CpG sites in the pparg promoter, further supporting its role in adipogenesis by increasing the gene expression of pparg , leptin , and glucose-6-phosphatase catalytic subunit (g6pc) in differentiated 3T3-L1 adipocytes [251]

Dai YL, Luk TH, Yiu KH, Wang M, Yip PM, et al