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Similarly, the overlay of the KAR 1 -bound AtHTL (PDB code: 4JYM and ShHTL3 (PDB code: 5DNU structures with GR24-binding proteins revealed that residues 157, 218, and/or 219 of the divergent clade ShHTLs and D14 sterically clashed with KAR 1 (Supplementary Fig

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Contrave's risks relate to stimulant effects and antidepressant warnings, while tirzepatide's primary concern is GI side effects during dose adjustment