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[DOI] [PMC free article] [PubMed] [Google Scholar] 96.Gan TT, Liao Q, Wang JH, et al
During therapy, doctors will regularly monitor IGF-1 levels in the blood to gauge the biological response to sermorelin
Total weight loss at 48-68 weeks on the combination is difficult to predict without clinical trial data, but based on individual compound data (retatrutide at 24-28.7% and the additive benefit seen with CagriSema), a reasonable estimate for the combination is 25-35% total body weight reduction in high responders
In practice, intermittent peptide dosing can simulate natural pulses and resuscitate downstream hormone rhythms instead of crudely increasing levels
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