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Increasing NRF2 activity has been proposed as a treatment approach for bipolar disorder, and activating the CaMKK2 signalling pathway represents a potential and viable mechanism to achieve this outcome [209]

Pregnant women and individuals with severe gastrointestinal disorders should also avoid these medications unless advised otherwise by their healthcare provider

doi:10.1016/j.ejpain.2008.06.004 [DOI] [PubMed] [Google Scholar] 25.Desideri I, Francolini G, Becherini C, et al

Key Points 1

Type of Specialists to Consult For professional help, you should turn to authorised specialists who can guide you related to safe use: Dermatologist General physician Endocronologist Pharmacist Make sure you share all your current medications and supplements, medical history, existing health and skin conditions, allergies, and dosages