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Liraglutide 3.0 mg resulted in an additional 6.2% weight loss from the initial average of 6.0% [42]

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However, significant variations in control types (placebo, MET, or intensive lifestyle), concomitant medications, and follow-up windows mean that a robust head-to-head ranking of strategies is still lacking

Unlike earlier weight-management medicines, retatrutide is a triple receptor agonist , meaning it simultaneously targets three distinct hormone receptors: glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors

Ultimately, the duration of use will depend on the dose tolerance, overall health, personal health goals, and the doctors advice