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The above portrayal of the gutbone axis in anti-osteoporosis, on the one hand, stimulates a broader management mindset for active health of the skeleton, and, on the other hand, highlights the key involvement of intestinal factors in systemic pathogenesis, which is expected to provide theoretical basis for disease intervention strategies that target the gut and the clinical implementation of micro-ecological preparations ( Figure 5 )

281,282,283 In the TME, Gln metabolic reprogramming is essential for the survival of tumor cells and immune cells, and there is competition for Gln uptake