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Notably, its effects on sperm concentration and total sperm count were superior to those achieved with testosterone replacement therapy (TRT), offering a novel therapeutic option for this patient population (70, 71)

Studies in rodents and non-human primates showed that semaglutide effectively lowered blood glucose levels, reduced body weight, and preserved -cells while maintaining a favorable safety profile

For example, GLP-1 RAs have been shown to be associated with an increase in growth hormone release in healthy patients

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