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Disruption of the immune system SAMe increases the suppression competency of regulatory T cells (Treg cells) in a dose-dependent manner via affecting the expression of FOXP3 (83), promoting the proliferation of CD8+cytotoxic T cells

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Taken together, all results observed in mentioned studies indicate a new underlying mechanism of mechanical overloading to the progression of OA, that is, the GPX4-associated ferroptosis pathway (Fig