A research peptide is a short chain of amino acids manufactured for laboratory and preclinical research rather than human or animal consumption
They have 6 clinical programs, a CLDN18.2 antibody in Ph3 (LM-302), a CCR8 antibody in Ph2 (LM-108), a SIRPa antibody in Ph1 (LM-101), a GPRC5D ADC in Ph1 (LM-305), a CEACAM5 biparatopic in Ph1 (LM-24C5), and a PD-1/VEGF bispecific in Ph1 (LM-299)
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When IGF-1 LR3 binds to the extracellular alpha subunits of IGF-1R, it triggers a conformational change that brings the intracellular beta subunits into close proximity, enabling trans-autophosphorylation of multiple tyrosine residues on the beta subunits' kinase domains
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