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Ann Rheum Dis (2006) 65 Suppl 3:iii89

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340 Furthermore, the increased production of inflammatory mediators like TNF- and the activation of stress kinases such as JNK, PKR, and IKK could promote the inhibitory serine phosphorylation of IRS-1, downregulate insulin signaling in the brain, and induce AD neurological dysfunction

Nagapan, T.S ., Lim, W.N., Basri, D.F