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Challenges include gastrointestinal side effects, nutritional deficiencies due to calorie reduction, muscle and bone loss, low long-term adherence with subsequent weight regain, and high costs, resulting in low cost-effectiveness
The 8.7% average reached at week 12 roughly doubles to 17.3% by week 24, representing the highest velocity weight loss of the entire protocol
this must be assessed by the trial team using the criteria set out in the trial protocol and site standard operating procedures
Just because a drug exists doesnt mean its accessible to everyone who needs it
In rodent models of diet-induced obesity, oral berberine consistently reverses this endocrine drift
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