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ABCA1 gene expression remained unchanged regardless of SREBP-2 silencing

The two independent pathways via glutathione reductases in cytosol and class III peroxidases in apoplast could maintain the balance of the GSH/GSSG cycle

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The result: IGF-1 LR3 stays active in serum 23 times longer than endogenous IGF-1 and reaches target tissues (skeletal muscle, cartilage, bone) with significantly higher free-fraction availability