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New basic and clinical research is clarifying the mechanistic relevance and therapeutic feasibility of multiple targets within the glutamate system for novel drug discovery, including NMDA and AMPA (-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors, metabotropic glutamate receptors, and other key regulatory proteins such as glycine transporter 1 and excitatory amino acid transporters

10.1038/224117a0 Nature

A significant difference in GPx activity and MDA levels was seen between the thyroid cancer patients before and after thyroidectomy in a study examining the change in OxS markers

We demonstrated that the ferroptosis inhibitors Fer-1 and Lip-1 protected against cell death induced by GSH depletion

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