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The C28-steroidal lactones withanolide A (WLA) and withaferin A (WA) appear to be essential for a significant portion of this action

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Interestingly, adult mice with modest isolated elevations in GH and IGF-1 levels have greater lean mass, improved lipid oxidation and glucose clearance 38 , while specific, temporal reductions in GH and IGF-1 in adults have been linked to deleterious metabolic effects, including impaired hepatic insulin action 38 , and reduced -cell mass and function 39

A better strategy is using melatonin during the initial weeks while Epitalon takes effect, then tapering off the supplement as natural production increases