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Hollow microneedles add a fourth mechanism that solid microneedles cannot: the molecule is delivered during channel formation, not after

Local delivery is preferable as it achieves the target site at the same concentration as it was prepared directly without passing through all the body barriers via the bloodstream and without losing biopolymer molecules

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This gives the prescribing physician a high degree of control over the biological outcomes being supported whether that is tissue repair, hormonal optimisation, immune function or cellular longevity

Paraffin sections were immunohistochemically stained using standard procedures