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Showing that a compound helps a rat heal from a surgical muscle wound tells us very little about whether it helps a human athlete recover faster between sessions

COX-2 selective NSAIDs (i.e., COX-2 inhibitors or coxibs) inhibit COX-2 more strongly than COX-1, resulting in less gastrointestinal side effects, but potential cardiovascular complications, most notably an increase in the risk of heart attack due to increased blood clotting propensity (see below) (Conaghan 2012)

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A study presented at the 2025 American Academy of Orthopaedic Surgeons meeting found that stopping semaglutide two weeks before hip and knee replacement was associated with lower rates of anesthesia-related complications

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