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At the conclusion of the STEP 1 trial, the average weight loss among the 1,961 participants averaged 14.9% of their initial body weight.[2] For example, if a participant started at 260 pounds and lost 14.9% of their body weight, they would have lost 38.7 pounds

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GLP-1 medications are a class of medications that help regulate appetite, improve feelings of fullness, and support metabolic health

optimized the BID siRNA delivery system, enabling efficient accumulation in the liver, which effectively reduces BID levels and is accompanied by a decrease in mitochondrial BAX and BAK, thereby improving NASH-related liver fibrosis and alleviating the inflammatory response [112]

It is temporary and reversible once the body stabilizes