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Expert consensus from major diabetes and obesity societies recommends against combining these substances without explicit provider oversight

Wang T, Gou Z, Wang F, Ma M, Zhai SD

10.1016/0263-7855(96)00018-5 J Mol Graph

and Jayson Lusk, Professor, Vice President and Dean of Oklahoma State Universitys Division of Agricultural Sciences and Natural Resources.

In some guidelines, diosmin is also discussed as a supportive therapy for lipoedema, as it improves microcirculation and reduces capillary fragility (lipoedema patients tend to bruise)